However Herd was much better. Without a doubt, it is always safest to use food to increase nutrient levels in our body. the body's heart function. Selenium is also a part of the enzymes that deiodinate thyroid hormones. 2010;95(8):406671. This can cause several health problems. When it is healthy, it produces the hormones that regulate many bodily functions: the body's metabolism rate. PubMed . Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. Selenium and the course of mild Graves orbitopathy. Without enough selenium, the thyroid is unable to function properly. Asia Pac J Clin Nutr. 2011;165(5):74552. She is the author of "The Thyroid Diet Revolution.". Rayman MP. Selenoprotein-related disease in a young girl caused by nonsense mutations in the SBP2 gene. Nat Rev Endocrinol. Low serum selenium levels also increased the risk for multiple thyroid nodules in women. Lescure A, Allmang C, Yamada K, Carbon P, Krol A. cDNA cloning, expression pattern and RNA binding analysis of human selenocysteine insertion sequence (SECIS) binding protein 2. Margaret P. Rayman . https://ods.od.nih.gov/factsheets/Selenium-HealthProfessional/#h7. CAS Effects of long-term selenium supplementation on the incidence of type 2 diabetes: a randomized trial. A severe selenium deficiency is characterized by cardiomyopathy, while a moderate deficiency usually results in symptoms such as muscular weakness and pain (7), along with dry skin (8). https://doi.org/10.1097/MED.0000000000000190. Results: The risk of thyroid disease was 69% higher for those living in the low-selenium county than for those in the adequate-selenium county. 2009;23(6):175865. Thomson CD, Campbell JM, Miller J, Skeaff SA. Selenium-dependent enzymes also have several modifying effects on the immune system. 47, 1995 . But in some studies on people with autoimmune thyroid diseases, selenium supplementation helped slow down the disease and generally reduce the problem (although it wasn't a cure). 2006;16(5):45560. Google Scholar. Rasmussen LB, Schomburg L, Khrle J, et al. PLoS Genet. Individuals who are taking high doses of thyroid medication (Levothyroxine, Synthroid) and continue to have uncontrolled hypothyroidism may benefit from IV selenium therapy. Clark LC, Combs GF Jr, Turnbull BW, et al. Guastamacchia E, Giagulli VA, Licchelli B, Triggiani V. Selenium and iodine in autoimmune thyroiditis. Sci Total Environ. Se deficiency has been associated with a variety of thyroid diseases, including myxoedematous cretinism, goitre, thyroid autoimmune disease and cancer. It also can cause your nails to get brittle and crack easily. J Clin Endocrinol Metab. I have been losing my hair, brittle nails. https://doi.org/10.1093/mutage/ges064. Selenium deficiency is also associated with male infertility and might play a role in Kashin-Beck disease, a type of osteoarthritis that occurs in certain low-selenium areas of China, Tibet, and Siberia [ 1, 2, 5, 6, 8, 22 ]. According to the National Institutes of Health, a healthy blood level of selenium is 8 micrograms (mcg)/dL or higher. Role of Selenium Deficiency in Pediatrics with Acquired Hypothyroidism. Department of Nuclear Medicine, Philipps University Marburg, Marburg, Germany, Georgetown University School of Medicine, Washington, DC, USA, 2019 Springer International Publishing AG, part of Springer Nature, Rayman, M.P., Duntas, L.H. 2021 Sep;199(9):3190-3204. doi: 10.1007/s12011-020-02444-w. Epub 2020 Oct 23. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Diagnostics. https://doi.org/10.1007/978-3-319-72102-6_9, DOI: https://doi.org/10.1007/978-3-319-72102-6_9. Quantitative data on the magnitude of the systemic inflammatory response and its effect on micronutrient status based on plasma measurements. Selenium is low in newly diagnosed Graves disease: a population-based study. 2005 Dec;26(7):944-84. doi: 10.1210/er.2001-0034. "Selenium is well-known to protect the thyroid," said study author . When you visit the site, Dotdash Meredith and its partners may store or retrieve information on your browser, mostly in the form of cookies. Best Pract Res Clin Endocrinol Metab. Contempre B, Le Moine O, Dumont JE, et al. Eating 2 brazil nuts per day will increase your selenium level as much as 100mcg of selenomethionine. https://doi.org/10.1007/s12016-010-8245-8. A review found selenium supplements in daily dosages of 100-300 mcg led to improved thyroid function at 6 months in people with Graves' disease, . According to science direct Severe selenium deficiency is vastly treated by combining selenium-rich foods and vet prescribed selenium supplements. For more information, please read our Privacy Policy. 2015;47(10):7216. I had surgery for Herd in the early 90s, but sty needed pepcid. sharing sensitive information, make sure youre on a federal When iodine deficiency goes hand-in-hand with selenium deficiency, it's essential to treat both nutrient deficits to restore the thyroid to . Selenium is important for the proper functioning of your thyroid gland. There is an inverse relationship between selenium status and thyroid volume, risk of goiter and risk of thyroid tissue damage in people with mild iodine deficiency. A number of research studies have shown key relationships between selenium supplementation and thyroid and immune function. Biol Trace Elem Res. Br J Nutr. Meanwhile, your hypothyroid symptoms continue to worsen because you are low in active thyroid hormone. Symptoms: 2009;145(5):50813. Hypothyroidism, which can be indicative of a selenium deficiency in an affected individual, is a condition characterized by an inability of the thyroid gland to produce an adequate amount of thyroid hormone. Selenium deficiency doesn't necessarily cause any obvious symptoms, but there are some signs to look for that can indicate that you may be low. In areas with severe selenium deficiency there is a higher incidence of thyroiditis due to a decreased activity of selenium-dependent glutathione peroxidase activity within thyroid cells. 2011;41(2):1907. 7 Ways How Selenium Can Benefit Your Thyroid 1.Adequate selenium levels can protect against autoimmune thyroid disease and goiter development in adults. PubMed This is because selenium plays a huge role in increasing antioxidant levels in the body. Kohrle J. Selenium and the thyroid. In fact, if you have undiagnosed selenium deficiency, it could be making your thyroid function worse. Selenium deficiency is further linked to more common issues such as thyroid dysfunction and male infertility. 2005;26(7):94484. Selenium is a mineral that's naturally found in some of the foods we eat. Like most things, you can overdo selenium supplementation as well. Since selenium is important for the conversion of T4 to T3, having a selenium deficiency can lead to symptoms of hypothyroidism, including fatigue, brain fog . Selenium upregulates CD4(+)CD25(+) regulatory T cells in iodine-induced autoimmune thyroiditis model of NOD.H-2(h4) mice. Selenium is also necessary for the conversion of the thyroid hormone thyroxine (T4) into its more active counterpart triiodothyronine (T3), [3] and as such a deficiency can cause symptoms of hypothyroidism, including extreme fatigue, mental slowing, goiter, cretinism, and recurrent miscarriage. Iodinethe building block and key ingredient of thyroid hormoneactually requires selenium in order to be synthesized properly into thyroid hormone. Nat Genet. 2022 Dotdash Media, Inc. All rights reserved, Mary Shomon is a writer and hormonal health and thyroid advocate. They underwent an accurate pediatric-endocrinologic diagnosis. PubMed Central How much selenium should I take for hyperthyroidism? Even for people who don't have a selenium deficiency, taking selenium supplements has been shown to have a considerable impact on the immune system, increasing the production of activated T-cells and natural killer cell activity, both of which assist in the immune response to disease, tumors, and infection. Eur Thyroid J. I am a family doctor that focuses on functional medicine, specifically balancing hormones. Stranges S, Marshall JR, Natarajan R, Donahue RP, Trevisan M, Combs GF, et al. If that isn't possible or if you have absorption issues due to chronic GI issues, adding a good quality selenium supplement may be necessary. CrossRef Unable to load your collection due to an error, Unable to load your delegates due to an error. Google Scholar. Moreover, it also plays an important role in decreasing oxidative stress. But whether selenium dietary supplements can help treat or reduce the risk of thyroid disease is not clear. As an essential trace mineral, selenium has wide-ranging health benefits for the human body, but primarily for thyroid health. They underwent an accurate pediatric-endocrinologic diagnosis. [Selenium deficiency and its dietary correction in patients with irritable bowel syndrome and chronic catarrhal colitis]. Selenium, the thyroid, and the endocrine system. Curr Opin Endocrinol Diabetes Obes. Accessed 29 Mar 2016. 2011;35(7):15405. Since selenium is essential to thyroid function it is no wonder that the symptoms of selenium deficiency symptoms of selenium deficiency are so close to symptoms of thyroid disease, especially hypothyroidism. In fact, selenium supplementation has been shown to improve immune function in patients that were deficient. The selenium appears to protect the thyroid from iodine at least in some part because it increases regulatory T cell levels. Mutations in the selenocysteine- binding protein 2 (SBP2) gene interfere with the synthesis of selenoproteins thus causing a multisystem selenoprotein deficiency disorder. Knezevic J, Starchl C, Tmava Berisha A, Amrein K. Nutrients. In: Luster, M., Duntas, L., Wartofsky, L. (eds) The Thyroid and Its Diseases. Rayman MP. I will restart Biotin. In addition to these important functions, studies on selenium benefits for thyroid have also proven it to be a crucial nutrient alongside iodine to convert T4 to T3 . 2008;52(11):123546. Dr. Whelchel is a family physician who specializes in functional medicine, especially hormone optimization. In humans, selenium deficiency has been linked to osteoarthropathy- diseases of bones and joints. For those with thyroid disease and low selenium levels, supplementation can be beneficial, but for those whose selenium levels are normal to high, supplementation could potentially result in toxicity. The reverse is also true. Iron deficiency anaemia in childhood and thyroid function. He grew up in the Texas Panhandle where he currently lives. Save my name, email, and website in this browser for the next time I comment. Stefanowicz FA, Talwar D, OReilly DS, Dickinson N, Atkinson J, Hursthouse AS, et al. They can then offer guidance on whether you might benefit from increasing your dietary selenium or adding supplements. Unable to load your collection due to an error, Unable to load your delegates due to an error. 2003;19(3-4):137-43. doi: 10.1002/biof.5520190306. Nutr Cancer. Karbownik-Lewiska M, Stpniak J, Iwan P, Lewiski A. Endocrine. Bookshelf https://doi.org/10.1056/NEJMoa1012985. 2014;99(4):E71923. A daily intake of fewer than 55 micrograms of selenium over a long period of time can hamper thyroid functioning, as well as lead to a decline in mental capabilities and immunity. Keshan Disease - A form of congestive cardiomyopathy caused by both Selenium deficiency and the presence of a mutated strain of . Survey on measurement of the concentrations of metals and other elements from the 2006 UK total diet study. 2011;364(20):192031. Endocr Rev. Both forms are good sources, but research has shown that using the organic form of selenium as a supplement may be more effective because your body absorbs more than 90% of organic selenium but only around 50% of the inorganic form. One study showed that taking iodine in the presence of LOW levels of selenium may actually increase your risk for thyroid tissue damage. Due to its overall effects in the body, research is being conducted on whether or not selenium supplementation may affect glucose metabolism, as well as help prevent cancer, thyroid disease, heart disease, and the cognitive decline that occurs as we age. Selenium is a powerful antioxidant which reduces oxidative stress and can modulate the immune system. The effect of antioxidant supplementation on superoxide dismutase activity, Cu and Zn levels, and total antioxidant status in erythrocytes of patients with Graves disease. official website and that any information you provide is encrypted Tan L, Sun W, Sang ZN, et al. Mutation in human selenocysteine transfer RNA selectively disrupts selenoprotein synthesis. Thank you for the article. 2005;184(3):45565. Biol Trace Elem Res. Carcinogenesis. 2003;23:1740. Disclaimer, National Library of Medicine Duntas LH. Having a deficiency of selenium does not in itself cause illness. https://doi.org/10.1016/j.ando.2011.03.019. Your body doesn't make selenium, so the only way you can get it is through food and/or supplements. Google Scholar. Content is reviewed before publication and upon substantial updates. Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemoprevention? Low population selenium status is associated with increased prevalence of thyroid disease. sharing sensitive information, make sure youre on a federal Therefore, I use a supplement periodically to keep my selenium level optimized. The upper tolerable level of selenium intake is set to 400 g per day in the USA[6] and 300 g per day in the EU[7]. A functional link between housekeeping selenoproteins and phase II enzymes. Mutations in the selenocysteine- binding protein 2 (SBP2) gene interfere with the synthesis of selenoproteins thus causing a multisystem selenoprotein deficiency disorder. An official website of the United States government. Effects Of Selenium Deficiency On The Thyroid Gland And Thyroid Associated Ophthalmopathy. Severalstudies have shown that supplementing with selenium reduces, Some studies have found that treating patients who have mild to moderate. It is past time for ALL of us to do that. More than 30% of subjects in the low-selenium area had thyroid disease compared with 18% of those in the adequate-selenium area. Selenoprotein gene nomenclature. Department of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK, Unit of Endocrinology Diabetes and Metabolism, Evgenidion Hospital, National and Kapodistrian University of Athens, Athens, Greece, You can also search for this author in Selenium acts as a "thyroid antioxidant" and is vital for the production of thyroid hormone and it is involved in the conversion of T4 (least active thyroid hormone) to T3 (most active form). Thanks for posting this information Dr. Whelchel. OGrady TJ, Kitahara CM, DiRienzo AG, Gates MA. Has it helped? Schmutzler C, Mentrup B, Schomburg L, Hoang-Vu C, Herzog V, Kohrle J. Selenoproteins of the thyroid gland: expression, localization and possible function of glutathione peroxidase 3. confirming the absence of iodine deficiency Biological Trace Element Research Vol. Curr Environ Health Rep. 2016. Eur J Endocrinol. Genetic variation in selenoprotein S influences inflammatory response. Duffield-Lillico AJ, Slate EH, Reid ME, Turnbull BW, Wilkins PA, Combs GF Jr, et al. 2002;284(13):22735. I have IBS and take a protonic. Several associations have been established between an individual's selenium status and HPT hormone levels. and transmitted securely. J Clin Invest. 1999;20(9):165766. MeSH Glutathione peroxidase 3 gene polymorphisms and risk of differentiated thyroid cancer. Since the production of iodized salt, the incidence of thyroid problems due to iodine deficiency in the United States is rare; however, 30 percent of the world's . Copyright text 2021 by Dr. Jeff Whelchel. Eur J Endocrinol. Best Pract Res Clin Endocrinol Metab. https://doi.org/10.1172/JCI84747. Other foods with good selenium content include: It's always best to start with natural food sources such as these. We go to great lengths to help users better understand their health; however, the content on this blog is not a substitute for medical guidance. 2016;24(15):85566. Bethesda, MD 20894, Web Policies 2015;48(3):75665. Both excessively high and low levels of selenium have been associated in several studies with an increased risk of disease. Selenium supplementation for Hashimotos thyroiditis: summary of a cochrane systematic review. Epub 2022 Jun 20. If you have chronic digestive issues, there is a good chance that you have inadequate selenium levels. Thyroid-Gut-Axis: How Does the Microbiota Influence Thyroid Function. Read our, Guide to Dietary Supplements and Thyroid Disease, The 5 Best Thyroid Supplements of 2022, According to a Dietitian, Goitrogens, Thyroid Disease, and Your Diet, Antibodies That Contribute to Thyroid Disease, What to Eat When You Have Hyperthyroidism, Hypothyroidism Nursing Diagnosis and Care Plans, Selenium and thyroid disease: From pathophysiology to treatment, Selenium and selenoproteins in immune mediated thyroid disorders, Selenium supplementation significantly reduces thyroid autoantibody levels in patients with chronic autoimmune thyroiditis: A systematic review and meta-analysis, Multiple nutritional factors and the risk of Hashimoto's Thyroiditis. Dumitrescu AM, Liao XH, Abdullah MS, et al. In case of selenium deficiency, the excessive amounts of Hydrogen peroxide generated led to immoderate production of T4 and damage of thyroid cells. It is always best to treat selenium deficiency by eating food rich in selenium. Epub 2005 Sep 20. Common variation in the DIO2 gene predicts baseline psychological well-being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients. This site is your resource for information and help on hormone issues. High-nitrate levels in drinking water may be a risk factor for thyroid dysfunction in children and pregnant women living in rural Bulgarian areas. Google Scholar. Thyroid. Effects of selenium deficiency on thyroid necrosis, fibrosis and proliferation: a possible role in myxoedematous cretinism. Selenium (Se) is an essential micronutrient present in human diet, entering in the composition of selenoproteins as selenocysteine (Se-Cys) amino acid. Optimizing the selenium level allows the thyroid to tolerate a wide range of iodine levels. Di Cosmo C, McLellan N, Liao XH, et al. eCollection 2020. 2016;5(1):5764. International Journal of Endocrinology. Along with other inputs like iodine and iron, selenium plays a key role in synthesizing the thyroid hormones that regulate your metabolism. Fairweather-Tait SJ, Bao Y, Broadley MR, Collings R, Ford D, Hesketh JE, et al. Selenium is not the only micronutrient essential to optimal thyroid function. https://doi.org/10.1172/JCI43653. 1990;10:2139. J Thyroid Res. J Endocrinol. Intestinal, digestive, or absorption issues like Crohn's disease, Living in an area with selenium-deficient soil, Having human immunodeficiency virus (HIV), Compromised immune system, resulting in getting sick more often, Seafood, such as shrimp, sardines, salmon, halibut, and tuna, Meats like beef steak, beef liver, ground beef, and ham. The food with the highest amount of selenium is brazil nuts. Selenium and thyroid function. I believe the evidence shows that it is okay to take iodine if you have Hashimoto's as long as you are also supplementing with selenium. Selenium works together with iodine to activate three different selenium-dependent iodothyronine deiodinases, which can then activate or deactivate thyroid hormones. Before Zhonghua Yu Fang Yi Xue Za Zhi. In fact, if you have undiagnosed selenium deficiency, it could be making your thyroid function worse. Selenoproteins involved in cellular antioxidative defence systems and redox control, such as the glutathione peroxidase (GPx) and the thioredoxin reductase (TxnRd) family, are involved in protection of the thyroid gland from excess hydrogen peroxide and reactive oxygen species produced by the follicles for biosynthesis of thyroid hormones. Thyroid volume decreased significantly in the group after iodine repletion. Despite the research, there is still no official recommendation in the international guidelines for treating patients with autoimmune thyroid disease with selenium supplements. Endocrine. - 210.65.88.143. Adaptive dysfunction of selenoproteins from the perspective of the triage theory: why modest selenium deficiency may increase risk of diseases of aging. 2015;100(11):4037717. Selenium is vital to our body's ability to convert T4 to T3, and has a balancing effect on our thyroid and immune health. Zinc and Selenium in Inflammatory Bowel Disease: Trace Elements with Key Roles? Source: Ann Ist Super Sanita. 2017 May;27(5):597610. https://doi.org/10.1007/s12020-014-0477-6. Am J Clin Nutr. 2015;167(2):22535. J Clin Endocrinol Metab. Santos LR, Duraes C, Mendes A, Prazeres H, Alvelos MI, Moreira CS, et al. Liu Y, Huang H, Zeng J, Sun C. Thyroid volume, goiter prevalence, and selenium levels in an iodine-sufficient area: a cross-sectional study. Marcocci C, Bartalena L. Role of oxidative stress and selenium in Graves hyperthyroidism and orbitopathy. Other health risks of selenium deficiency also . Selenium supplementation fails to correct the selenoprotein synthesis defect in subjects with SBP2 gene mutations. 2013;79(4):58490. Sengupta A, Carlson BA, Weaver JA, Novoselov SV, Fomenko DE, Gladyshev VN, et al. Selenium is critical for the endocrine system, especially the thyroid gland, which affects metabolism, as well as heart, brain, and muscle function. Bednarek J, Wysocki H, Sowiski J. Oxidative stress peripheral parameters in Graves disease: the effect of methimazole treatment in patients with and without infiltrative ophthalmopathy. Shen F, Cai WS, Li JL, et al. The role of iodine and selenium in autoimmune thyroiditis. Nat Genet. J Am Diet Assoc. Italian survey about the clinical use of selenium in thyroid disease. Essentially what selenium is doing is helping to regulate the immune system, which will decrease the damage caused to the tissues of the eyes. Why is My T4 Low (and What Can I Do About It)? The course of Autoimmune Thyroiditis in WOMEN. That's why it is critical that you find a doctor that will check a complete thyroid panel and will listen to you and your symptoms, and not solely depend on lab results to manage your thyroid problem. Zinc, vitamin D, vitamin A, and most importantly iodine, play crucial roles in thyroid hormone production and subsequent thyroid health. https://doi.org/10.1007/978-3-319-72102-6_9, Shipping restrictions may apply, check to see if you are impacted, http://www.thyroid.org/iodine-deficiency/, https://doi.org/10.1016/j.ando.2011.03.011, https://doi.org/10.1016/j.beem.2014.02.005, https://doi.org/10.1007/s00268-011-1096-5, https://doi.org/10.1007/s12011-008-8296-3, https://doi.org/10.1186/1471-2458-13-1153, https://doi.org/10.1007/s00423-011-0788-5, https://doi.org/10.1016/j.beem.2009.08.002, https://doi.org/10.1016/j.ando.2011.03.019, https://doi.org/10.1007/s12016-010-8245-8, https://doi.org/10.1007/s12020-014-0477-6, https://doi.org/10.1097/MED.0000000000000190, https://doi.org/10.1007/s12011-015-0304-9, https://doi.org/10.1371/journal.pone.0110886, https://doi.org/10.1080/01635580903191569, http://tna.europarchive.org/20140306205048/http://www.food.gov.uk/science/research/surveillance/fsisbranch2009/survey0109#.Vw0TvHNwbcs, Tax calculation will be finalised during checkout. 2015;22(5):4026. Leo M, Bartalena L, Rotondo Dottore G, et al. Selenium deficiency a factor in endemic goiter persistence in sub-Saharan Africa. Healthyhormones.us does not intend to provide medical advice. Your article is the first information I have found ( actually my husband) that mentioned selenium as a possible cause. 2014;28(4):495506. According to a 2011 study, people with mild TED who took selenium supplements had reduced symptoms compared with those who took a placebo (inactive pill). 2008;42(9):6403. 2005;37(11):124752. A double-blind intervention study found that . Selenium Deficiency. Duntas LH, Benvenga S. Selenium: an element for life. Eur Thyroid J. Curr Opin Endocrinol Diabetes Obes. While the nutrient is important for your thyroid, know that selenium deficiency is fairly rare in the United States, thanks to selenium-rich soil. Rayman MP. 2016. http://www.thyroid.org/iodine-deficiency/. At a minimum, you should look at these micronutrients as possible culprits: iron, zinc, selenium, and biotin. J Clin Endocrinol Metab. Curr Opin Endocrinol Diabetes Obes. PubMed Would you like email updates of new search results? https://doi.org/10.1089/thy.2009.0351. Erythrocyte selenium concentration as a marker of selenium status. 2005;38(1):138. Selenium and human health. My T3 is low, T4 high. What have you used to treat it. When that conversion process is reduced, the free T4 levels will begin to rise and the free T3 levels will begin to fall. 2005;37:123441. Gaitan E. Goitrogens in food and water. She is the author of "The Thyroid Diet Revolution.". Khrle J. Selenium and the thyroid. [149] Gene. https://doi.org/10.1055/s-0042-110491. Interestingly, serum selenium decreased slightly (5%) during this period. Se deficiency has been associated with a variety of thyroid diseases, including myxoedematous cretinism, goitre, thyroid autoimmune disease and cancer. Proc Nutr Soc. 2013;32(5):83742. Eschler DC, Hasham A, Tomer Y. Hello. 2011;25(6):1793814. 2002;291(12):27985. Gatseva PD, Argirova MD. Rayman MP, Thompson AJ, Bekaert B, Catterick J, Galassini R, Hall E, et al. Also, those who have suboptimal levels of T3, TSH, T4, and rT3 are likely to improve with IV Selenium Therapy. However, there is also evidence that excessive iodine can also damage the thyroid gland and may even increase the incidence of autoimmune thyroid disease such as Hashimoto's. Generally, selenium acts as an antioxidant that works with vitamin E. Some epidemiologic studies associate low . Clin Nutr. While the odds of a deficiency are pretty low for most, there are some people for whom the risk is greater. Iodine is a controversial issue in regards to thyroid health. McCann JC, Ames BN. The role of selenium in thyroid autoimmunity and cancer. World J Surg. The nutrient is essential for thyroid function. I really like them but are hard to get. Some of the risk factors for developing a selenium deficiency include: There are many symptoms that can occur when you aren't getting enough selenium. Toulis KA, Anastasilakis AD, Tzellos TG, et al. 2015;15(4):28892. He is married and has 3 awesome children. Keshteli AH, Hashemipour M, Siavash M, Amini M. Selenium deficiency as a possible contributor of goiter in schoolchildren of Isfahan, Iran. CAS Jonklaas J, Danielsen M, Wang H. A pilot study of serum selenium, vitamin D, and thyrotropin concentrations in patients with thyroid cancer. A polymorphism in the promoter region of the selenoprotein S gene (SEPS1) contributes to Hashimotos thyroiditis susceptibility. 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