Sodium starch glycoate is a white to off-white, tasteless,. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. 67 Requirements 68 Definition. It is used in various skin-care products. Nonetheless, it should be used only within the range of its Acceptable Daily Intake to prevent any untoward reactions. It also works as a thickening agent. The compound is also tasteless and generally odorless. Sodium starch glycolate absorbs water rapidly, resulting in swelling which leads to rapid disintegration of tablets and granules. National Library of Medicine. You can return the item for any reason in new and unused condition: no shipping charges. VIVASTAR & EXPLOTAB, sodium starch glycolate, are superdistintegrants made from potato starch by carboxymethylation and crosslinking for tablets and other oral solid dosage forms. Immediate-Release Formulations Produced via Twin-Screw Melt Granulation: Systematic Evaluation of the Addition of Disintegrants. Sodium starch glycolate absorbs water rapidly, resulting in swelling which leads to rapid disintegration of tablets and granules. GLYCOLYS Sodium starch glycolate is a range of superdisintegrants for different formulation needs. Sample Policy: Within a certain price range free samples are available. Sodium Starch Glycolate (Maize & Potato), 25Kg 250/ Kg Get Latest Price Packaging Size: 25Kg Grade Standard: BP Purity: >99% Manufacturer: Jai Radhe Saless Grade: Pharma Grade Packaging Type: Drum read more. Settling volume was also observed to be different for the disintegrant from two sources. We also offer shipping services through the air, sea, or couriers like FedEx or UPS. We have developed different grades of TABSOL to meet specific needs, such as withstanding high shear granulation, acidic conditions or with a . Sodium starch glycolate is a commonly used super-disintegrant employed to promote rapid disintegration and dissolution of IR solid dosage forms. [1] [2]. Effect of molecular structure variation on the disintegrant action of sodium starch glycolate. AAPS J. *The previous sign-offs and Stage 6 postings are included as below: Promoting the Quality of Medicines Plus (PQM+) Program, Download the Sodium Starch Glycolate monograph, 15-Nov-2021, Rev.3 (Correction of Sign-Off Cover Sheet), Previous Stage 6 posting in PF 30 (4), 2004, The United States Pharmacopeial Convention, Minor verbiage changes to align with the PDG Stage 6 sign-off document. Sodium starch glycolate is a commonly used super-disintegrant employed to promote rapid disintegration and dissolution of IR solid dosage forms. SODIUM STARCH GLYCOLATE TYPE B POTATO [II] Common Name; UNII Resources. The compound may be purchased in bulk or lesser quantities from legitimate ingredient suppliers like Nutriavenue. The CAS number for Carboxymethyl Ether sodium salt or Sodium Starch Glycolate is 9063-38-1. Excipient (pharmacologically inactive substance). The ADI may vary depending on the individual users age, weight, and overall physical condition. Several forms of Sodium Starch Glycolate are available in the market. Type B, in contrast, has a pH level of 3.0 to 5.0. It is manufactured by chemical modification of starch . There are also other minor verbiage changes to align with PDG Stage 6 sign-off document. Dissolve 0.5 g in 10 ml ofdistilled water R.Add0.5mlof hydrochloric acid R1 and dilute to 15 ml with distilled water R. Iron:maximum50ppm. Sodium Starch Glycolate can be used in the synthesis of capsules for delivery of drugs or medicaments. Type of Posting: Notice of Adoption of Harmonized Standard, Posting Date: 28Feb2014 (updated 28Feb2017*). Color reaction Reagent required 0.005M Iodine Procedure: Dissolve 2 g sample and disperse in 100 ml of water. Effects of modification and incorporation techniques on disintegrant properties of wheat (Triticum aestivum) starch in metronidazole tablet formulations. It is mostly used in the manufacturing of paper, pulp, dyeing, textiles, detergents, cosmetics . Bookshelf Without a disintegrant, tablets may not dissolve appropriately and may effect the amount of active ingredient absorbed, thereby decreasing effectiveness. [1] [2]. Sodium Starch Glycolate Market - Insights: The Sodium Starch Glycolate industry is estimated to grow at a significant CAGR in the upcoming period as the scope and its applications are rising . 2.7.2 Sodium Starch Glycolate (SSG) SSG is the sodium salt of cross-linked carboxymethyl starch. Sample Available: Yes. Considering that it is an inert compound having no active ingredient properties, it is considered safe for use among individual users. These are SSG Type A, SSG Type B, and SSG Type C. Essentially, Types A and B of Sodium Starch Glycolate are cross-linked salts of sodium that are partly O-carboxymethylated potato starch. Highly effective when used intra- and extra-granularly in wet and dry granulated formulations. It is used as a disintegrant, a suspending agent and as a gelling agent. WHAT IS SODIUM STARCH GLYCOLATE? Jai Radhe Sales Paldi, Ahmedabad TrustSEAL Verified View Mobile Number Contact Supplier Request a quote Excipient (pharmacologically inactive substance). Molecular Formula. Would you like email updates of new search results? Its property of insolubility is remarkable, with complete insolubility in most organic solvents, and even in water. Sodium Starch Glycolate is a pharmaceutical excipient and superdisintegrant composed of the sodium salt of cross-linked carboxymethyl starch. (Na)x CAS Number: 9063-38-1 NACRES: NA.24 Pricing and availability is not currently available. Sodium starch glycolate is the sodium salt of carbomethyl ether. It offers excellent formulation and commercial benefits to the pharmaceutical industry and demonstrates strong swelling properties upon contact with water and other media. Type C, however, is manufactured through physical dehydration by cross-linking of sodium salt of partly carboxymethylated starch. Zarmpi P, Flanagan T, Meehan E, Mann J, Fotaki N. Int J Pharm. SSG has more hydrophilic substitution than its hydrophilic group,. Sodium Starch Glycolate contains about 2.8 to 5.0 percent of Sodium, depending on its type, and not more than 7 percent of Sodium Chloride. The https:// ensures that you are connecting to the Take 5 ml of above dispersion and add 0.05 ml 0.005M iodine. Available for Android and iOS devices. Sodium starch glycolate is the sodium salt of carboxymethyl ether. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Sodium Starch Glycolate By Maruti Chemicals. Last updated on Dec 6, 2021. Sodium starch glycolate is used as a pharmaceutical grade dissolution excipient for tablets and capsules. The Acceptable Daily Intake (ADI) for Sodium Starch Glycolate is at 13mg/kg body weight per day among adults and 80 mg/kg body weight per day among children. (Na)x CAS Number: 9063-38-1 NACRES: NA.24 Pricing and availability is not currently available. sodium starch glycolate, a modified starch; Flavours. 2021 Jun 16;22(5):183. doi: 10.1208/s12249-021-02056-0. Our GLYCOLYS product provides this benefit for swallowable tablets, orally dispersible tablets and hard capsules. Sodium starch glycolate is very hygroscopic. Evaluation of the functional equivalence of crospovidone NF from different sources. The following are among the well-known uses of Sodium Starch Glycolate: As a dissolution excipient, Sodium Starch Glycolate helps maintain effectiveness of active ingredients in tablets and capsules. It may contain NMT 7.0% of Sodium N = normality of the perchloric acid Chloride. Disclaimer, National Library of Medicine This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Overview of pharmaceutical excipients used in tablets and capsules. GLYCOLYS Sodium starch glycolate provides pharmaceutical and nutraceutical manufacturers with a range of superdisintegrants for different formulation needs. Thus, it helps stabilize active ingredients in medications and dietary supplement products. The usual concentration of Solvostar . It is produced by cross-linking and carboxy methylation of potato starch. Each drum contains a net weight of about 25 kilograms. Sodium starch glycolate is the sodium salt of carboxymethyl ether. Sodium starch glycolate (SSG) is a superdisintegrant suitable for a variety of tablet and capsule formulations. Solvostar - Sodium starch glycolate (SSG) is widely used in oral pharmaceuticals as a disintegrate in tablet and capsule formulations. As a dissolution excipient, Sodium Starch Glycolate works as a disintegrant. Sodium starch glycolate was chosen because of its high swelling capacity. It may contain not more than 7.0 percent of Sodium Chloride. Generally, the compound works by absorbing water several times its weight when ingested orally. Primojel sodium starch glycolate is a superdisintegrant suitable for various tablet and capsule formulations. The Sodium Starch Glycolate monograph will be incorporated into and become official with the Second Supplement to USP 37-NF 32. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Thus, its inclusion in formulations for drugs and dietary supplement products is not negligible but rather quite significant. It is widely recognised in the pharmaceutical industry for its adaptability and compatibility with many active pharmaceutical ingredients, and processing technologies. The .gov means its official. This action of the compound essentially results in higher bioavailability of active ingredients and improved dissolution rates. No precipitate is formed. and heat to boiling. AAPS PharmSciTech. PUGVIEW FETCH ERROR: 403 Forbidden National Center for Biotechnology Information 8600 Rockville Pike, Bethesda, MD, 20894 USA Contact Policies FOIA HHS Vulnerability Disclosure National Library of Medicine National Institutes of Health Sodium starch glycolate is the sodium salt of a cross-linked partly O-69 carboxymethylated starch. An official website of the United States government. Our company offers high-quality products at very affordable prices. We comply with the HONcode standard for trustworthy health information. Changed description of procedure to align with the PDG Stage 6 sign-off document, including add 2mL of 15% potassium carbonate, and heat to boiling. Starch glycolates are also of rice, wheat or corn origin. Sodium starch glycolate is the sodium salt of carboxymethyl ether. Sodium Starch USP Standard comes in varieties such as type A, type B, PH, and those with sodium content. BBF-04564. Starch glycolates are of rice, potato, wheat or corn origin. SSG is derived from starch with two chemical modifications: substitution (to increase hydrophilicity) and cross-linking (to reduce solubility and gel formation upon contact with water) ( Shah & Augsburger, 2002 ). Return this item for free. 2016 Mar-Apr;73(2):469-78. Skip Navigation. CAS: 9063-38-1 Synonyms: Sodium Carboxymethyl Starch Sodium Starch Glycolate, pH 5.5-7.5, Type A, NF is used as a pharmaceutical grade dissolution excipient for tablets and capsules. 100 INR Get latest price. BlowTab - Sodium Starch Glycolate. If you want to request a quotation or place an order, please instead add the desired products to your cart and then request a quotation or order from the cart. Certificate of Analysis. 1985 Jun;74(6):647-50. doi: 10.1002/jps.2600740613. Starch glycolates are of rice, potato, wheat or corn inception. The color of SSG varies from white to off-white tone. 2004. http://www.pformulate.com/nastgly.htm Accessed October 17, 2011. Specification. Sodium Starch Glycolate is a pharmaceutical ingredient used primarily as a dissolution excipient for tablets and capsules. Allow to cool in ice water. Roquette has been producing sodium starch glycolate for more than 20 years. National regulations Germany AwSV/VwVwS Annex reference : Water hazard class (WGK) 1, slightly hazardous to water (Classification according to VwVwS, Annex 3; WGK No 2988) Studies show that Sodium Starch Glycolate is also very beneficial in improving medication bioavailability. Sodium Starch Glycolate may also be used as a gelling agent. 9063-38-1 - Sodium starch glycolate - Searchable synonyms, formulas, resource links, and other chemical information. Check if any food or ingredient has gluten Simply scan a food product with Fig. Standard performance test. Sodium Starch Glycolate, are potato based cellulose fibers have been cross linked - that is, have been either ionically or covalently bonded, so that it forms a chain of cellulose, rather than individual, short fibers. Excipients. It must be distinguished from Carboxymethylcellulose sodium which is often used as a bulk-forming agent and a laxative. Sodium Starch Glycolate is widely used in oral pharmaceuticals as a disintegrant in capsule and tablet formulations. Surface dissolution UV imaging for characterization of superdisintegrants and their impact on drug dissolution. Sodium starch glycoate is a white to off-white, tasteless, odorless, relatively free flowing powder. *Should you have any questions about the Sodium Starch Glycolate monograph, please contact Dr. Tong (Jenny) Liu (240-221-2072 or jyl@usp.org ). Diosgenin: A Plant Steroid for Improved Hormonal Balance, 2 Main Manufacturing Processes Of NMN Crystalline Powder, Dec. 7th Ingredients Price: Recommended Alpha Lipoic Acid, Nutritional Vitamin Ingredients Market 2022: Status, Development & Forecast, Key Country Dietary Supplement Market Overview 2022. Please enable it to take advantage of the complete set of features! Contents 1 History 2 Preparation Starch glycolates are of rice, potato, wheat or corn origin. FOIA J Young Pharm. Sodium starch glycoate is a white to off-white, tasteless, odorless, relatively free flowing powder. and transmitted securely. Sodium Starch Glycolate is gluten free. In a letter to the Agency dated June 28, 1994, Generichem Corp, now located at 755 Union Boulevard in Totowa, New Jersey 07511-0457 requested that 40 CFR 180.1001 (c) and (e), be amended by establishing an exemption from the requirement of a tolerance for residues of sodium starch glycolate. It is otherwise known for its other generic names which include SSG, Sodium salt of Carboxymethyl Ether, Carboxymethyl Starch Sodium salt, Sodium Starch Glycolate Type A potato, and Sodium Starch Glycolate Type B. The action was assigned pesticide petition (PP . Important Announcement. Get Contact details & address of companies manufacturing and supplying Sodium Starch Glycolate, CAS No- 9063-38-1 across India. Compendial assays provide an accurate representation of the chemical quality of an excipient, but they are not useful in describing the physical properties associated with the excipients. It is used as a disintegrant, a suspending agent and as a gelling agent. Sodium Starch Glycolate is widely used in oral pharmaceuticals as a disintegrant in capsule and tablet formulations. It is generally used alongside active ingredients in pharmaceutical drugs and dietary supplements. The pH and assay requirements for Type A and Type B are set forth in the accompanying table. The Properties, Specifications, Monograph and Uses of Sodium Starch Glycolate: CAS Number 9063-38-1, EINECS EC Number 618-597-7, HS Code 29389090. Types A, B, and C of Sodium Starch Glycolate differ in terms of pH, Sodium Chloride content, and Assay Sodium. Sodium starch glycolate absorbs water rapidly, resulting in swelling which leads to rapid disintegration of tablets and granules. Read-more Registered trademark (s) of Roquette Frres Documents and Samples Description. The physical properties of sodium starch glycolate remain unchanged for up to 3 years if it is stored at moderate temperatures and humidity. It has been reported in the literature that the source of starch, particle size, amount of sodium chloride (reaction by-product), viscosity, degree of substitution and cross-linking affect the functionality of sodium starch glycolate. Its unique combination of performance and cost-effectiveness has established as globally recognized and widely used product in the pharmaceutical industry. Please see the NLM Technical Bulletin article for more information. There are three major types of Sodium Starch Glycolate. Is Fadogia Agrestis Illegal in the Market? Starch is chemically modified by the introduction of carboxy methyl groups and phosphate groups to provide cross-linking. Download the Sodium Starch Glycolate PDG Stage 6 sign-off Cover Pages. 7. Generally, there are no side effects associated with Sodium Starch Glycolate supplementation as it does not have a direct effect on individual users. The chemical information in the CAS database is curated by expert scientists and includes information of common and frequently regulated . How can we help? Also, the compound is safely used for the said purpose in dietary supplement products. 2.7.2 Sodium Starch Glycolate (SSG) SSG is the sodium salt of cross-linked carboxymethyl starch. Sodium starch glycolate Synonym: More Synonyms Chemical & Physical Properties. Sodium starch glycolate type A potato is the sodium salt of carboxymethyl ether of starch from potato origin. Their unique combination of performance and cost-effectiveness has established them as globally recognized and widely used products in the pharmaceutical industry. Sodium Starch Glycolate should be safe for patients with celiac and other gluten-related disorders. Check ingredients faster with the free Fig app! Sodium starch glycolate (SSG) is a viscous and thixotropic thickening agent that can be used in gravy, sauces, salad dressing and other products. Price: $34.57. Sodium starch glycolate absorbs water rapidly, resulting in swelling which leads to rapid disintegration of tablets and granules. The extent of liquid uptake and settling volume was observed to be higher for the smaller sieve fractions in either medium, Although differences were also observed in the axial and radial disintegration force measurements of the pure disintegrant compacts, disintegration and dissolution of a model drug (hydrochlorothiazide) from either the soluble or insoluble core did not reveal any significant differences between the multiple sources. 2004. http://www.pformulate.com/nastgly.htm Accessed October 17, 2011. It is made by modifying starch chemically, such as carboxymethylation to increase hydrophilicity and cross-linking to decrease solubility. Sodium Starch Glycolate is a typical super-disintegrant used to accelerate rapid disintegration and dissolution of IR solid dosage forms. Under the guidelines of this diet, croscarmellose sodium should be specifically avoided because of its ability to promote overgrowth of flora, both good and bad. The use of Sodium Starch Glycolate in drugs and dietary supplement products has been shown to increase the effectiveness of active ingredients as the compound helps improve overall bioavailability. Sodium starch glycolate is used as a pharmaceutical grade dissolution excipient for tablets and capsules. SSG is derived from starch with two chemical modifications: substitution (to increase hydrophilicity) and cross-linking (to reduce solubility and gel formation upon contact with water) ( Shah & Augsburger, 2002 ). X. ChemIDplus is moving to PubChem in December 2022. 1 rating. Sodium starch glycolate is used as a pharmaceutical grade dissolution excipient for tablets and capsules. Before It is believed that Sodium Starch Glycolate works as a suspending agent by filming around active ingredient particles and decreasing inter-particulate attraction. It improves supplement ingredient combination The combination of ingredients in a supplement product may also be improved with compounds such as Sodium Starch Glycolate. Careers. CAS. II. Being strict to quality, we follow ethical manufacturing practices and bring products that comply with defined industry standards. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Drug Topics (online). As to Assay Sodium, the ranges for Types A, B and C are 2.8% to 4.2%, 2.0% to 3.4%, and 2.8% to 5.0%, respectively. SSG powder is odorless, tasteless, hygroscopic & free-flowing. Both Type A and Type C have a pH level of 5.5 to 7.5. Sodium Starch Glycolate is the sodium salt of carboxymethyl ether of starch classified as a disintegrant and an excipient. Founded in 1999, Jai Radhe Sales is a customer focused exporter of Active Pharmaceutical Ingredients, Agro Chemicals, Pellets, Phyto chemicals, Excipients & Fine Chemical s. We are seller of Tizanidine hydrochloride. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices. Medically reviewed by Drugs.com. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Sodium starch glycolate absorbs water rapidl More Nakoda Corporation Indore, India 208-209, Sheba Complex, 562, M.G. SODIUM STARCH GLYCOLATE EXTRA PURE is not on the REACH Candidate List SODIUM STARCH GLYCOLATE EXTRA PURE is not on the REACH Annex XIV List 15.1.2. The options from the pharmacist were to make calls to the manufacturers, or she offered . Brand names for the compound include Primojel, EXPLOTAB, and GLYCOLYS. If you are looking for a place to buy bulk Sodium Starch Glycolate powder, Nutriavenue is the best choice. The site is secure. Glycolic acid is widespread in nature. EXPLOTAB, sodium starch glycolate, is a superdisintegrant made from potato starch by carboxymethylation and crosslinking. For any questions about the PDG and its processes, please see the Pharmacopeial Harmonization Group or contact Richard Lew at (240-221-2060 or rll@usp.org). Being the sodium salt of carboxymethyl ether, Sodium Starch Glycolate is a white to off-white, odourless, tasteless, free-flowing powder. Federal government websites often end in .gov or .mil. Starch glycolates are of rice, potato, wheat or corn origin. Sodium Starch Glycolate, or SSG, is a cross-linked variant of Carboxymethyl starch. official website and that any information you provide is encrypted The botanic source and degrees of cross-linking and substitution have been optimized to give rapid water uptake . Jai Radhe Sales is supplier for Sodium starch glycolate. Research also shows that Sodium Starch Glycolate may work as a suspending excipient agent. It is manufactured by chemical modification of starch, i.e., carboxymethylation to enhance hydrophilicity and cross-linking to reduce solubility. 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